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Current Projects

 

A randomised controlled trial of eicosapentaenoic acid (EPA) and/or aspirin for colorectal adenoma (or polyp) prevention during colonoscopic surveillance in the NHS Bowel Cancer Screening Programme: The seAFOod polyp prevention trial.
EME Ref:  09/100/25
Lead:  Professor Mark Hull
Senior Lecturer at Respiratory Medicine Research Group
Insitution University of Leeds
Project Brief www.eme.ac.uk/projectfiles/0910025info.pdf (38kb)opens in a new window
Protocol Awaiting.

Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in Acute
lung injury to Reduce Pulmonary dysfunction (HARP).
EME Ref:  08/99/08
Lead:  Dr Danny McAuley
Senior Lecturer at Respiratory Medicine Research Group
Insitution The Queen's University of Belfast
Project Brief www.eme.ac.uk/projectfiles/089908info.pdf (40kb)opens in a new window
Protocol Awaiting.

Efficacy and mode of action of mesalazine in the treatment of diarrhoea predominant irritable bowel syndrome (IBS-D).
EME Ref:  09/20/16
Lead:  Professor Robin Spiller
Professor of Gastroenterology
Insitution University of Nottingham
Project Brief www.eme.ac.uk/projectfiles/092016info.pdf (38kb)opens in a new window
Protocol Awaiting.

ROLARR: Robotic versus Laproscopic Resection for Rectal Cancer
EME Ref:  08/52/01
Lead:  Mr David Jayne
Senior Lecturer in Surgery
Insitution University of Leeds
Project Brief www.eme.ac.uk/projectfiles/085201info.pdf (38kb)opens in a new window
Protocol www.eme.ac.uk/projectfiles/085201protocol.pdf (1.43mb)opens in a new window

Amino acid regimen and intravenous lipid composition in preterm parenteral nutrition: a randomised double blind controlled trial.
EME Ref:  08/99/04
Lead:  Dr Sabita Uthaya
Consultant and Honorary Senior Lecturer
Insitution Imperial College of Science, Technology and Medicine
Project Brief www.eme.ac.uk/projectfiles/089904info.pdf (39kb)opens in a new window
Protocol www.eme.ac.uk/projectfiles/089904protocol.pdf (199kb) opens in a new window

Does metformin reduce excess birthweight in offspring of obese pregnant women? A randomised controlled trial of efficacy, exploration of mechanisms and evaluation of other pregnancy complications.
EME Ref:  08/246/09
Lead:  Professor Jane Norman
Professor of Maternal and Fetal Health
Insitution University of Edinburgh
Project Brief www.eme.ac.uk/projectfiles/0824609info.pdf (41kb)opens in a new window
Protocol www.eme.ac.uk/projectfiles/0824609protocol.pdf (591kb)opens in a new window

Study of Tolerance to Oral Peanut
EME Ref:  08/99/18
Lead:  Dr Pamela Ewan & Dr Andrew Clark
Allergy Consultants
Insitution University of Cambridge
Project Brief www.eme.ac.uk/projectfiles/089918info.pdf (38kb)opens in a new window
Protocol www.eme.ac.uk/projectfiles/089918protocol (104kb) opens in a new window

Peroxisome Proliferator-Activated Receptor-gamma: a novel therapeutic
target for asthma?
EME Ref:  08/246/02
Lead:  Professor Alan Knox
Professor of Respiratory Medicine
Insitution University of Nottingham
Project Brief www.eme.ac.uk/projectfiles/0824602info.pdf (40kb)opens in a new window
Protocol www.eme.ac.uk/projectfiles/0824602protocol.pdf (399kb)opens in a new window

Does Levodopa (3,4-dihydroxy-L-phenylalanine) drug treatment in
combination with routine NHS occupational and physical therapy, delivered
early after stroke within a stroke service, improve functional recovery
including walking and arm function?
EME Ref:  08/43/61
Lead:  Professor Bipinchandra Bhakta
Charterhouse Professor of Rehabilitation Medicine
Insitution University of Leeds
Project Brief www.eme.ac.uk/projectfiles/084361info.pdf (140kb)opens in a new window
Protocol www.eme.ac.uk/projectfiles/084361protocol.pdf (642kb)opens in a new window

Antiglucocorticoid augmentation of antiDepressants in Depression (The
ADD study).
EME Ref:  08/43/39
Lead:  Professor Ian Nicol Ferrier
Honorary Consultant/Professor at the Institute of Neuroscience
Insitution Royal Victoria Infirmary
Project Brief www.eme.ac.uk/projectfiles/084339info.pdf (123kb) opens in a new window
Protocol Awaiting.

A randomised controlled trial of losartan as an anti-fibrotic agent in non-alcoholic steatohepatitis.
EME Ref:  08/43/15
Lead:  Professor Christopher Day
Dean of Medicine
Insitution Newcastle University
Project Brief www.eme.ac.uk/projectfiles/084315info.pdf (122kb) opens in a new window
Protocol Awaiting.

Parent-determined oral montelukast therapy for preschool wheeze with
stratification for arachidonate-5-lipoxygenase (ALOX5) promoter genotype.
EME Ref:  08/43/03
Lead:  Professor Jonathan Grigg
Professor of Paediatric Respiratory Medicine
Insitution Barts and the London School of Medicine and Dentistry
Project Brief www.eme.ac.uk/projectfiles/084303info.pdf (38kb)opens in a new window
Protocol www.eme.ac.uk/projectfiles/084303protocol.pdf (239kb)opens in a new window

Neural and biomechanical correlates of response to the use of an anklefoot
cast provided to improve walking recovery early after stroke. A Phase II trial.
EME Ref:  08/43/25
Lead:  Professor Valerie Pomeroy
Professor of Neurorehabilitation
Insitution University of East Anglia
Project Brief www.eme.ac.uk/projectfiles/084325info.pdf (37kb) opens in a new window
Protocol www.eme.ac.uk/projectfiles/084325protocol.pdf (146kb) opens in a new window

Imaging perfusion deficits and thrombolysis safety and efficacy in acute ischaemic stroke. The Third International Stroke Trial (IST-3).
EME Ref:  08/43/52
Lead:  Professor Joanna Wardlaw
Professor of Applied Neuroimaging
Insitution University of Edinburgh
Project Brief www.eme.ac.uk/projectfiles/084352info.pdf (38kb) opens in a new window
Protocol www.eme.ac.uk/projectfiles/084352protocol.pdf (1608kb) opens in a new window

Remote ischaemic preconditioning in renal transplantation.
EME Ref:  08/52/02
Lead:  Professor Raymond MacAllister
Professor of Clinical Pharmacology
Insitution UCL (University College London)
Project Brief www.eme.ac.uk/projectfiles/085202info.pdf (37kb) opens in a new window
Protocol www.eme.ac.uk/projectfiles/085202protocol.pdf (474kb) opens in a new window





 

 

 

 



 

 
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The Efficacy and Mechanism Evaluation programme is funded by the MRC and managed by the NIHR Evaluation, Trials and Studies Coordinating Centre (NETSCC), based at the University of Southampton. 

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